Is that called "pollinate?" I was thinking of fertilizer when I read your title.
Generations of selfing with no interference of other pollen (genetic materials) creates a species. On boundaries between species, you get various natural hybrids.
I found a good explaination how to do it on troymeyers.com/flasking and then look for article # 33. It is not really recommended because you need genetic diversity. Getting 2 plants from 2 different parents/breeders is much better.
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