William, as to whether there is a significant difference, it depends upon the chemistry of your water supply, so nobody can answer precisely, but I prefer starting with pure water as I can knowingly control exactly what my plants get. If I had a water analysis, I could do the same, but having a well, it varies, and I'd be paying for testing all the time.
There are three classes of nitrogen compounds used in fertilizers, nitrates, ammoniacals, and urea. The first two can be utilized directly by the plants, but urea must decompose into ammonium compounds first. There is some evidence that it takes bacterial intervention for that to happen, and there is debate whether that happens effectively in non-soil media, so orchid growers often avoid it.
I urge everyone to read Dr. Bill Argo's 5-part series on plant nutrition, which was published in some 2003 IPA journals. He sent me the pdf's, which can be seen here:
Plant Nutrition